Clinical Trials - Cancer

Short Study Name	Protocol Title	Principal Investigator	Site(s)
S0307	Phase III Trial Of Bisphosphonates As Adjuvant Therapy For Primary Breast Cancer	Norwood Anderson, MD	Wheaton Franciscan Healthcare - Wauwatosa, Elmbrook Memorial, and St. Francis

TAILORx	Program for the Assessment of Clinical Cancer Tests (PACCT-1): Trial Assigning IndividuaLized Options for Treatment: The TAILORx Trial	Norwood Anderson, MD	Wheaton Franciscan Healthcare - Wauwatosa, Elmbrook Memorial, and St. Francis

E1505	A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (≥ 4 cm) – IIIA Non-Small Cell Lung Cancer (NSCLC)	Norwood Anderson, MD	Wheaton Franciscan Healthcare - Wauwatosa, Elmbrook Memorial, and St. Francis

E3805	CHAARTED: ChemoHormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer	Norwood Anderson, MD	Wheaton Franciscan Healthcare - Wauwatosa, Elmbrook Memorial, and St. Francis

E5202	A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients with Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers	Norwood Anderson, MD	Wheaton Franciscan Healthcare - Wauwatosa, Elmbrook Memorial, and St. Francis

B-43	A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy	Norwood Anderson, MD	Wheaton Franciscan Healthcare - Wauwatosa, Elmbrook Memorial, and St. Francis

Preference	Patient Preference for Receiving the Diagnosis of Breast Cancer: The Preference Study	Phyllis Wattleworth, RN	Wheaton Franciscan Healthcare - Wauwatosa, Elmbrook Memorial, St. Francis, All Saints Wheaton Franciscan - St. Joseph

RTOG 0614	A Randomized Phase III Double Blind Placebo Controlled Trial of Memantine For Prevention of Cognitive Dysfunction In Patients Receiving Whole Brain Radiotherapy	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

S0221	Phase III Trial of Continuous Schedule AC + G vs Q 2 Week Schedule AC Followed by Paclitaxel Given Either Every 2 Weeks of Weekly for 12 Weeks as Postoperative Adjuvant Therapy in Node-Positive or High Risk Node Negative Breast Cancer.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

NSABP B-42	A Clinical Trial to Determine the Efficacy of Five Years of Letrozole Compared to Placebo in Patients Completing Five Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women with Hormone Receptor Positive Cancer.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

RTOG 0413/NSABP B-39	A Randomized Phase III Study of Conventional Whole Breast Irradiation vs Partial Breast Irradiation for Women with Stage 0,I, or II Breast Cancer.	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

S0307	A Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

TAILORx	Trial Assigning Individual Options for Treatment (Rx)	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

E5103	A Double-Blind Phase III Trial of Doxorubicin and Cyclophosphamide Followed by Paclitaxel With Bevacizumab or Placebo in Patients With N+ or High Risk N- Breast Cancer.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

VIRGO	An Observational Study of Treatment Patterns and Safety Outcomes For Metastatic or Locally Recurrent Breast Cancer	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

NSABP R-04	Trial comparing Preoperative Radiation Therapy and Capecitabine With or Without Oxaliplatin With Preoperative Radiation Therapy and Continuous Intravenous Infusion of 5-FU With or Without Oxaliplatin in the Treatment of Patients With Operaable Carcinoma of the Rectum.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

CALGB 80405	A Phase III Trial of Irinotecan/5-FU/Leucovorin or Oxaliplatin/5-FU/Leucovorin With Bevacizumab or Cetuximab (C225) or With the Combination of Bevacizumab and Cetuximab for Patients With Untreated Metastatic Adenocarcinoma of the colon or Rectum.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

E5202	A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin vs 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients With Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

RTOG 0436	A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin and Radiation for Patients With Esophageal Cancer Who are Treated Without Surgery.	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

RTOG 0534	A Phase III Trial of Short Term Androgen Deprivation With Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) In Prostate Cancer Patients With A Rising PSA After Radical Prostatectomy.	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

LORHAN	Longitudinal Oncology Registry of Head and Neck Carcinoma	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

E1305	A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

E1505	A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (>4cm) - IIIA Non-Small Cell Lung Cancer (NSCLC).	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

S0424	A Molecular Epidemiology Case-Series Study of Non-Small Cell Lung Cancer in Smoking and Non-Smoking Women and Men.	Richard Odders, MD	Wheaton Franciscan Healthcare - All Saints

RTOG 0617	A Randomized Phase III Comparison of Standard-Dose (60 Gy) vs High Dose (74 Gy) Conformal Radiotherapy With Concurrent and Consolidation Carboplatin/Paclitaxel in Patients With Stage IIIA/IIIB Non-Small Cell Lung Cancer.	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

CALGB 30610/RTOG 0538	Phase III Comparison of Thoracic Radiotherapy Regimens in Patients With Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide.	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

MIND-Q	Mindfulness Based Cognitive Training And Its Impact on a Psychological Well-Being & Quality of Life in Cancer Patients.	Christopher David	Wheaton Franciscan Healthcare - All Saints

RTOG 0815	A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

RTOG 0831	A Randomized Double-Blinded, Placebo-Controlled Phase III Trial To Evaluate the Effectiveness of a Phosphodiesterase 5 Inhibitor Tadalafil, in Prevention of Erectile Dysfunction in Patients Treated With Radiotherapy for Prostate Cancer	James Taylor, MD	Wheaton Franciscan Healthcare - All Saints

Wyeth 3004/ExteNET	A Randomized Double-Blind Placebo-Controlled Trial of Neratinib (HKI-272) After Trastuzumab in Women With Early-Stage HER-2/neu Overexpressed/amplified Breast Cancer	Young Choi, MD	Wheaton Franciscan Healthcare - All Saints

For information on enrolling in clinical trials, please call or email:

Kelli Holton, Regulatory Affairs Assistant

(414) 874-4541

kelli.holton@wfhc.org

All Saints Research Department: (262) 687-5057