Clinical Trials

Clinical Research Available to You at Wheaton Franciscan Cancer Care

Cancer research that involves people is called a clinical trial. After laboratory and animal testing, promising methods go on to several phases of clinical trials which take place in medical centers, hospitals and doctors’ offices. These studies follow carefully designed plans in order to compare a new unapproved method of diagnosis or treatment to standard care. The studies are sponsored by organizations such as the National Cancer Institute, drug companies and medical institutions.

Clinical trials look for answers in all phases of cancer care:

Prevention
Diagnosis
Treatment
Management of symptoms of cancer or symptoms associated with the treatment of cancer.

A clinical trial may be a treatment option for many patients with cancer. If a clinical trial is available as a treatment option that you may wish to consider, your doctor will discuss the possible benefits and drawbacks with you and will provide materials explaining the research study.

The following clinical trials in cancer treatment are available at all of our Milwaukee Cancer Care facilities:

Lung E1505

Colon E5202

Prostate E3805

Breast PACCT-1

S0307

B-43

Ovarian GOG-0218

The following clinical trials are available through All Saints Cancer Care in Racine.

Breast
S0221 Phase III Trial of Continuous Schedule Adriamycin/Cytoxan Plus G versus an Every 2 Week Schedule Adriamycin/Cytoxan, Followed by Paclitaxel Given Either Every 2 Weeks or Weekly for 12 Weeks as Postoperative Adjuvant Therapy in Node- Positive or High Risk Node Negative Breast Cancer.

RTOG 0413/B-39 A Randomized Phase III Study of Conventional Whole Breast Irradiation versus Partial Breast Irradiation for Women with Stage 0, I, or II Breast Cancer.

TAILORx Trial Assigning Individual Options for Treatment (Rx) a study assigning treatment based on the Oncotype DX recurrence score for women with hormone receptor positive breast cancer.

VIRGO AVF4349n An Observational Study of Treatment Patterns and Safety Outcomes AVF4349n For Metastatic or Locally Recurrent Breast Cancer.

Colorectal
NSABP-R-04 A Clinical Trial Comparing Preoperative Radiation Therapy and Capecitabine with or without Oxaliplatin with Preoperative Radiation Therapy and Continuous Intravenous Infusion of 5-Fluorouracil with or without Oxaliplatin in the Treatment of Patients with Operable Carcinoma of the Rectum.

CALGB 80405 A Phase III Trial of Irinotecan / 5-FU / Leucovorin or Oxaliplatin / 5-FU / Leucovorin with Bevacizumab, or Cetuximab (C225), or with the Combination of Bevacizumab and Cetuximab for Patients with Untreated Metastatic Adenocarcinoma of the Colon or Rectum

E5202 A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients with Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers.

GU-Prostate
RTOG 0534 A Phase III Trial Of Short Term Androgen Deprivation With Pelvic Lymph Node Or Prostate Bed Only Radiotherapy (SPPORT) In Prostate Cancer Patients With A Rising PSA After Radical Prostatectomy

Small Cell Lung
CALGB 30610/RTOG 0538 Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide

Non-Small Cell Lung
E1505 A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (> 4 cm) -IIIA Non-Small Cell Lung Cancer (NSCLC)

S0424 A Molecular Epidemiology Case-Series Study of Non-Small Cell Lung Cancer in Smoking and Non-Smoking Women and Men.

RTOG 0617 A Randomized Phase III Comparison Of Standard- Dose (60 Gy) Versus High Dose(74 Gy) Conformal Radiotherapy with Concurrent and Consolidation Carboplatin/Paclitaxel in Patients with Stage IIIA/IIIB Non-Small Cell Lung Cancer

Brain
RTOG 0614 A Randomized, Phase III, Double Blind Placebo controlled Trial of Memantine For Prevention of Cognitive Dysfunction In Patients Receiving Whole Brain Radiotherapy

Head and Neck
E1305 A Phase III Randomized Trial of Chemotherapy With or Without Bevacizumab in Patients with Recurrent or Metastatic Head and Neck Cancer.

The National Cancer Institute maintains a comprehensive database of cancer clinical trials available throughout the country which can be accessed at http://www.cancer.gov/clinicaltrials

For more information on clinical trials please call our Oncology Clinical Research Office at 414-778-7543. For information in Racine call (262) 687-5000.